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SEC inhibitor KL-1

CAS No. 900308-84-1

SEC inhibitor KL-1 ( KL-1 )

Catalog No. M24926 CAS No. 900308-84-1

SEC inhibitor KL-1 exhibits a dose-dependent inhibitory effect on AFF4-CCNT1 interaction (Ki: 3.48 μM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    SEC inhibitor KL-1
  • Note
    Research use only, not for human use.
  • Brief Description
    SEC inhibitor KL-1 exhibits a dose-dependent inhibitory effect on AFF4-CCNT1 interaction (Ki: 3.48 μM).
  • Description
    SEC inhibitor KL-1 exhibits a dose-dependent inhibitory effect on AFF4-CCNT1 interaction (Ki: 3.48 μM). SEC inhibitor KL-1 is a potent, selective super elongation complex (SEC) inhibitor and disrupts the interaction between the SEC scaffolding protein AFF4.
  • Synonyms
    KL-1
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    SEC
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    900308-84-1
  • Formula Weight
    345.8
  • Molecular Formula
    C18H16ClNO4
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:41.67 mg/mL (120.51 mM; Need ultrasonic)
  • SMILES
    CC1=C(C=C(C=C1)Cl)NC(=O)C(=O)CC(=O)C2=CC(=CC=C2)OC
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Liang K, et al. Targeting Processive Transcription Elongation via SEC Disruption for MYC-Induced CancerTherapy. Cell. 2018 Oct 18;175(3):766-779.
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